Figure 3.

Persistently elevated uCXCL9 after treatment for acute cellular rejection (ACR) detects subclinical intragraft infiltrates despite a progressive decline in serum creatinine. (a) Clinical course depicting changes in serum creatinine and uCXCL9 (day 0 is the date of the biopsy, 20 days posttransplant). Colored horizontal bars depict time during which each drug was administered (key: upper right panel a). Blue star represents the nadir serum creatinine within the initial 6 months posttransplant. Red dashed line is drawn at the 200 pg/ml threshold for CXCL9 positivity. (b−d) Representative periodic acid–Schiff stained sections of biopsy 1 (Bx1), 2 (Bx2), and 3 (Bx3) depicted in (a) showing areas of mononuclear cell infiltration in each biopsy. (e) Quantitative Banff scores as read by the local pathologist for the 3 biopsies.