Table 3.
Synergistic activities of N-carboxy pyrrolidine analogs in combination with colistin against A. baumannii strain 2208. MIC of compound and colistin is the concentration in the clear well (well with lowest concentrations and no growth). MIC of colistin alone is 1.5-3.1 μg/mL
| Compound in combination with colistin | MIC of colistin in combination (μg/mL) | MIC of compound in combination (μg/mL) | ΣFIC | Effect |
|---|---|---|---|---|
| 1 | 0.39 | 12.5 | 0.31 | Synergy |
| 2 | 0.19 | 25 | 0.25 | Synergy |
| 4 | 0.19 | 25 | 0.25 | Synergy |
| 6 | 0.19 | 25 | 0.25 | Synergy |
| 7 | 0.19 | 50 | 0.38 | Synergy |
| 8 | 0.39 | 12.5 | 0.19 | Synergy |
| 10 | 0.39 | 50 | 0.5 | No synergy/Synergy |
| 11 | 0.39 | 50 | 0.75 | No synergy |
| 12 | 0.78 | 6.25 | 0.28 | Synergy |
| 23 | 3.1 | n/a | n/a | No synergy |
| 24 | 0.39 | 25 | 0.37 | Synergy |
| 26 | 1.56 | n/a | n/a | No synergy |
| 27 | 0.39 | 100 | 1 | No synergy |
| 28 | 0.39 | 100 | 1 | No synergy |