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. Author manuscript; available in PMC: 2017 Dec 18.
Published in final edited form as: Curr Opin Pharmacol. 2013 Jun 28;13(4):582–587. doi: 10.1016/j.coph.2013.06.002

Figure 2. Epigenomic features of TLR-responsive promoters and enhancers under basal and activated conditions.

Figure 2

A prototypic enhancer is illustrated at left and a prototypic promoter at right. Blue circles represent histone octomers. Lines emerging from the circles represent histone tails. LDTF; lineage determining transcription factor, GTF; general transcription factor, STDF; signal-dependent transcription factor. H3K4me1/2; histone H3 mono or di-methylated at lysine 4. H3K4me3; histone H3 trimethylated at lysine 4. H3K27me3; Histone H3 tri-methylated at lysine 27. H4K20me3; histone H4 trimethylated at lysine 20. H3K27ac; histone H3 acetylated at lysine 27.