FIG. 5.
Complement inhibition with SSL7 results in increased production of chemoattractive chemokines in tumor microenvironment. qRT-PCR performed on tumor tissues of mice treated with PBS or CVF showed significantly higher expression [fold increase over HPRT (hypoxanthine guanine phosphoribosyl transferase) (murine housekeeping gene)] of chemokines: CCL5 (2.42 vs. 3.61; p = 0.001), CXCL10 (4.1 vs. 6.7; p = 0.001), and CXCL11 (0.038 vs. 0.06; p = 0.008). *p < 0.05, **p < 0.01, ***p ≤ 0.001