Table 2.
Protein name | Protein abbreviation | Normalized spot volume controls | Normalized spot volume CKD | Loading value in OPLS-DA |
---|---|---|---|---|
Proteins with lower expression in CKD | ||||
Vimentin_1 | VIME | 1.58 ± 0.26 | 0.94 ± 0.28a | −0.1675 |
Vimentin_2 | VIME | 1.29 ± 0.56 | 0.68 ± 0.35a | −0.1372 |
Serum albumin_1 | ALBU | 2.52 ± 1.05 | 1.31 ± 0.54a | −0.1140 |
Annexin A5_1 | ANXA5 | 2.15 ± 1.38 | 0.95 ± 0.77b | −0.1003 |
Proteins with higher expression in CKD | ||||
α-1-Microglobulin/bikunin precursor | AMBP | 0.53 ± 0.13 | 2.14 ± 0.52a | 0.1734 |
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic | GPDA | 1.02 ± 0.29 | 1.67 ± 0.41a | 0.1438 |
Glyceraldehyde 3-phosphate dehydrogenase | GAPDH | 1.10 ± 0.42 | 1.88 ± 0.59a | 0.1438 |
Annexin A6 | ANXA6 | 1.09 ± 0.34 | 2.28 ± 0.70a | 0.1399 |
Transthyretin | TTHY | 1.17 ± 0.43 | 2.73 ± 0.95a | 0.1323 |
α-1-Antitrypsin_1 | A1AT | 1.20 ± 0.45 | 1.78 ± 0.51b | 0.1306 |
α-1-Antitrypsin_2 | A1AT | 1.16 ± 0.44 | 1.66 ± 0.46b | 0.1259 |
14-3-3 protein zeta/delta | 1433Z | 1.21 ± 0.32 | 1.74 ± 0.56b | 0.1036 |
Vimentin_3 | VIME | 1.49 ± 0.72 | 2.08 ± 0.82 | 0.1024 |
Vimentin_4 | VIME | 1.42 ± 0.62 | 1.91 ± 0.79 | 0.0971 |
Annexin A5_2 | ANXA5 | 1.11 ± 0.54 | 1.67 ± 0.75 | 0.0947 |
α-1-Antitrypsin_3 | A1AT | 1.42 ± 0.49 | 1.53 ± 0.50 | 0.0907 |
14-3-3 protein epsilon | 1433E | 1.20 ± 0.35 | 1.48 ± 0.42 | 0.0858 |
Serum albumin_2 | ALBU | 1.13 ± 0.23 | 1.25 ± 0.18 | 0.0839 |
In cases in which 2 or more spots were identified as the same protein, spots are distinguished by successive numbering (e.g., vimentin_1, vimentin_2 etc.).
P ≤ 0.01 for differences between groups (Student t test).
P ≤ 0.05 for differences between groups (Student t test).