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. 2017 Jul 29;2(6):1208–1218. doi: 10.1016/j.ekir.2017.07.007

Table 2.

Adipose tissue protein spots significant in the OPLS-DA analysis and identified by LC-MS/MS.

Protein name Protein abbreviation Normalized spot volume controls Normalized spot volume CKD Loading value in OPLS-DA
Proteins with lower expression in CKD
Vimentin_1 VIME 1.58 ± 0.26 0.94 ± 0.28a −0.1675
Vimentin_2 VIME 1.29 ± 0.56 0.68 ± 0.35a −0.1372
Serum albumin_1 ALBU 2.52 ± 1.05 1.31 ± 0.54a −0.1140
Annexin A5_1 ANXA5 2.15 ± 1.38 0.95 ± 0.77b −0.1003
Proteins with higher expression in CKD
α-1-Microglobulin/bikunin precursor AMBP 0.53 ± 0.13 2.14 ± 0.52a 0.1734
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic GPDA 1.02 ± 0.29 1.67 ± 0.41a 0.1438
Glyceraldehyde 3-phosphate dehydrogenase GAPDH 1.10 ± 0.42 1.88 ± 0.59a 0.1438
Annexin A6 ANXA6 1.09 ± 0.34 2.28 ± 0.70a 0.1399
Transthyretin TTHY 1.17 ± 0.43 2.73 ± 0.95a 0.1323
α-1-Antitrypsin_1 A1AT 1.20 ± 0.45 1.78 ± 0.51b 0.1306
α-1-Antitrypsin_2 A1AT 1.16 ± 0.44 1.66 ± 0.46b 0.1259
14-3-3 protein zeta/delta 1433Z 1.21 ± 0.32 1.74 ± 0.56b 0.1036
Vimentin_3 VIME 1.49 ± 0.72 2.08 ± 0.82 0.1024
Vimentin_4 VIME 1.42 ± 0.62 1.91 ± 0.79 0.0971
Annexin A5_2 ANXA5 1.11 ± 0.54 1.67 ± 0.75 0.0947
α-1-Antitrypsin_3 A1AT 1.42 ± 0.49 1.53 ± 0.50 0.0907
14-3-3 protein epsilon 1433E 1.20 ± 0.35 1.48 ± 0.42 0.0858
Serum albumin_2 ALBU 1.13 ± 0.23 1.25 ± 0.18 0.0839

In cases in which 2 or more spots were identified as the same protein, spots are distinguished by successive numbering (e.g., vimentin_1, vimentin_2 etc.).

a

P ≤ 0.01 for differences between groups (Student t test).

b

P ≤ 0.05 for differences between groups (Student t test).