Table 2.
Association of the presenting demographic and clinical features of 78 patients with their initial episode of acquired thrombotic thrombocytopenic purpura with their presenting kidney function
| Patient features | KDIGO Stage |
P value | |||
|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | ||
| Patients (no.) | 33 | 25 | 12 | 8 | |
| Age in years (median) | 38 | 41 | 40.5 | 46.5 | 0.353 |
| Race (black, %) | 13 (39) | 8 (32) | 6 (50) | 3 (38) | 0.811 |
| Gender (female, %) | 25 (76) | 18 (72) | 11 (92) | 6 (75) | 0.630 |
| Body mass index (median) | 32.5 | 30.0 | 38.1 | 31.9 | 0.503 |
| Hypertension (no., %) | 6 (18) | 7 (28) | 4 (33) | 4 (50) | 0.286 |
| Diabetes (no., %) | 3 (9) | 1 (4) | 4 (33) | 0 | 0.053 |
| Severe neurologic abnormalities (no., %) | 14 (42) | 9 (36) | 6 (50) | 3 (38) | 0.944 |
| Hematocrit (%) (median) | 21 | 21 | 21.5 | 21.5 | 0.572 |
| Platelet count (μl × 10-3) (median) | 10 | 11 | 12 | 15 | 0.534 |
| LDH (U/L) (median) | 1302 | 1803 | 1578 | 2048 | 0.627 |
KDIGO, Kidney Disease: Improving Global Outcomes; LDH, lactate dehydrogenase.
Hypertension and diabetes preceded the occurrence of thrombotic thrombocytopenic purpura, documented by requirement for daily treatment. Severe neurologic abnormalities were defined as coma, stroke, seizures, or transient focal signs. Data for hematocrit, platelet count, and LDH values were the most abnormal values on the day of diagnosis ± 7 days. None of the demographic and clinical features were associated with KDIGO AKI stage. A test for trend of the data for hypertension was also not significant (P = 0.059).