Table 2.
Characteristics of patients according to FGF23 tertiles
| Characteristics | All patients (n = 845) |
FGF23 tertile 1 (n = 281) |
FGF23 tertile 2 (n = 282) |
FGF23 tertile 3 (n = 282) |
P valuea |
|---|---|---|---|---|---|
| Recipients | |||||
| Age (yr) at inclusion, mean ± SD | 49 ± 14 | 48 ± 13 | 49 ± 14 | 51 ± 14 | 0.02 |
| Gender, male, n (%) | 492 (58) | 165 (59) | 150 (53) | 177 (63) | 0.07 |
| Duration of dialysis before transplantation (mo), median (Q1–Q3) | 34 (12–70) | 32 (11–66) | 36 (13–68) | 36 (13–75) | 0.39 |
| First transplantation | 669 (79) | 222 (79) | 231 (82) | 216 (77) | 0.30 |
| Transplantation vintage (mo), median (Q1–Q3) | 12 (12–13) | 12 (12–13) | 12 (12–13) | 12 (12–14) | 0.51 |
| Donors | |||||
| Living donor | 185 (22) | 75 (27) | 63 (22) | 47 (17) | 0.02 |
| Age (yr), mean ± SD | 53 ± 16 | 51 ± 16 | 51 ± 17 | 57 ± 16 | <0.0001 |
| Cold ischemia duration, h (Q1–Q3) | 18 (9–25) | 17 (3–23) | 18 (4–25) | 19 (13–26) | 0.03 |
| Delayed graft function | 249 (30) | 58/278 (21) | 82/276 (30) | 109/280 (39) | <0.0001 |
| Immunology: HLA mismatch A, B, and DR <3, n (%) | 347 (41) | 128 (46) | 108 (38) | 111 (39) | 0.17 |
| Clinical and biological parameters at first evaluation | |||||
| BMI, median (Q1–Q3) | 25 (22–28) | 24 (22–27) | 24 (21–27) | 25 (23–28) | 0.0004 |
| Systolic blood pressure (mm Hg), median (Q1–Q3) | 132 (120–144) | 130 (119–142) | 130 (118–141) | 136 (123–149) | <0.0001 |
| GFR (ml/min per 1.73 m2), median (Q1–Q3) | 54 (42–64) | 59 (51–69) | 55 (44–64) | 44 (33–56) | <0.0001 |
| Ionized calcium mmol/l, median (Q1–Q3) | 1.24 (1.20–1.29) | 1.24 (1.20–1.29) | 1.24 (1.20–1.29) | 1.24 (1.20–1.30) | 0.98 |
| Phosphate, mmol/l, median (Q1–Q3) | 0.85 (0.74–0.99) | 0.84 (0.74–0.98) | 0.85 (0.73–0.99) | 0.88 (0.75–1.02) | 0.20 |
| Tm phosphate/GFR | 0.62 (0.47–0,79) | 0.65 (0.49–0.80) | 0.65 (0.51–0.81) | 0.57 (0.43–0.76) | 0.0002 |
| 25-OHD μg/l, median (Q1–Q3) | 23 (15–31) | 23 (15–30) | 24 (16–31) | 22 (15–31) | 0.45 |
| Calcitriol, ng/l, median (Q1–Q3) | 46 (33–63) | 46 (34–61) | 50 (35–68) | 44 (31–59) | 0.003 |
| PTH ng/l, median (Q1–Q3) | 82 (56–136) | 70 (51–102) | 80 (57–130) | 106 (65–176) | <0.0001 |
Categorical variables are presented as numbers (%), and continuous variables are presented as mean (SD) or median (Q1, Q3) as appropriate
BMI, body mass index; FGF, fibroblast growth factor; GFR, glomerular filtration rate; 25-OHD, 25-dihydroxyvitamin D; PTH, parathyroid hormone; Q1, first quartile; Q3, third quartile.
a
P represents tests of significance from one-way analysis of variances, Kruskal-Wallis test, or χ2 test.