Table 3.
Univariate analysis of characteristics associated with the composite of graft failure or death
| Characteristics | Univariate HR (95% CI) | P value |
|---|---|---|
| Recipients | ||
| -Age at inclusion | 1.03 (1.02–1.04) | <0.0001 |
| -Gender, male | 1.18 (0.87–1.58) | 0.28 |
| -Duration of dialysis before transplantation, mo | 1.003 (1.001–1.005) | 0.0007 |
| -First transplantation | 0.62 (0.45–0.85) | 0.003 |
| -Transplantation vintage, mo | 1.01 (0.99–1.03) | 0.23 |
| Donors | ||
| -Living donor | 0.54 (0.35–0.82) | 0.004 |
| -Age | 1.02 (1.01–1.03) | <0.0001 |
| -Cold ischemia duration, h | 1.03 (1.01–1.04) | <0.0001 |
| -Delayed graft function | 2.18 (1.63–2.92) | <0.0001 |
| - Extended donor criteria | 2.03 (1.50–2.75) | <0.0001 |
| Immunology: HLA mismatch A, B, and DR <3 | 0.96 (0.72–1.29) | 0.78 |
| Clinical and biological parameters at first evaluation | ||
| -BMI | 1.00 (0.97–1.03) | 0.92 |
| -Systolic blood pressure (mm Hg) | 1.02 (1.01–1.03) | <0.0001 |
| -GFR (ml/min per 1.73 m2) | 0.95 (0.94–0.96) | <0.0001 |
| -Ionized blood calcium mmol/l | 2.49 (0.47–13.3) | 0.29 |
| -Phosphate | 3.78 (1.86–7.66) | 0.0002 |
| -25-OHD | 0.98 (0.96–0.99) | 0.0006 |
| -Calcitriol | 0.99 (0.98–0.99) | 0.002 |
| -Log PTH | 3.59 (2.34–5.51) | <0.0001 |
| -FGF23a | 1.01 (1.00–1.01) | 0.04 |
| -FGF23 tertile 3 versus tertile 1 | 2.81 (1.96–4.03) | <0.0001 |
| -FGF23 tertile 2 versus tertile 1 | 1.52 (1.02–2.26) | 0.04 |
BMI, body mass index; CI, confidence interval; FGF, fibroblast growth factor; HLA, human leukocyte antigen; HR, hazard ratio; 25-OHD, 25-dihydroxyvitamin D; PTH, parathyroid hormone.
a
The hypothesis of proportional hazards was not verified for LogFGF23; therefore FGF23 was used.