Table 6.
Association of FGF23 and outcomes in the 48 months after FGF23 measurement after adjustment for mGFR and other variablesa
| Composite outcome within 48 mo | Hazard ratio (95% CI) | P value |
|---|---|---|
| FGF23 adjusted for mGFR | ||
| log FGF23 | 3.36 (2.11–5.33) | <0.0001 |
| FGF23 adjusted for mGFR and other variablesa | ||
| log FGF23 | 3.01 (1.79–5.04) | <0.0001 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR | ||
| FGF23 tertile 2 | 1.29 (0.71–2.34) | 0.40 |
| FGF23 tertile 3 | 2.00 (1.14–3.52) | 0.02 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR and other variablesa | ||
| FGF23 tertile 2 | 1.38 (0.74–2.60) | 0.31 |
| FGF23 tertile 3 | 1.85 (1.01–3.39) | 0.04 |
| Death within 48 mo | ||
|---|---|---|
| FGF23 adjusted for mGFR | ||
| log FGF23 | 1.62 (0.83–3.13) | 0.15 |
| FGF23 adjusted for mGFR and other variablesa | ||
| log FGF23 | 1.74 (0.85–3.54) | 0.13 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR | ||
| FGF23 tertile 2 | 1.00 (0.51–1.96) | 0.99 |
| FGF23 tertile 3 | 1.35 (0.70–2.59) | 0.36 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR and other variablesa | ||
| FGF23 tertile 2 | 1.00 (0.50–2.03) | 0.99 |
| FGF23 tertile 3 | 1.37 (0.70–2.71) | 0.36 |
| Graft failure within 48 mo (Fine and Gray model, taking into account competing risk of death) | ||
|---|---|---|
| FGF23 adjusted for mGFR | ||
| log FGF23 | 5.29 (3.07–9.11) | <0.0001 |
| FGF23 adjusted for mGFR and other variablesa | ||
| log FGF23 | 5.74 (2.87–11.49) | <0.0001 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR | ||
| FGF23 tertile 2 | 2.75 (0.77–9.75) | 0.12 |
| FGF23 tertile 3 | 4.24 (1.27–14.1) | 0.02 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR and other variablesa | ||
| FGF23 tertile 2 | 3.59 (0.78–16.5) | 0.10 |
| FGF23 tertile 3 | 5.02 (1.13–22.3) | 0.03 |
| Graft failure within 48 mo (cause-specific Cox model) | ||
|---|---|---|
| FGF23 adjusted for mGFR | ||
| log FGF23 | 5.46 (2.94–10.2) | <0.0001 |
| FGF23 adjusted for mGFR and other variablesa | ||
| log FGF23 | 5.83 (2.80–12.1) | <0.0001 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR | ||
| FGF23 tertile 2 | 2.63 (0.73–9.50) | 0.14 |
| FGF23 tertile 3 | 4.20 (1.21–14.5) | 0.02 |
| Tertile FGF23 (reference = tertile 1) adjusted for mGFR and other variablesa | ||
| FGF23 tertile 2 | 3.30 (0.72–15.2) | 0.12 |
| FGF23 tertile 3 | 4.74 (1.06–21.1) | 0.04 |
CI, confidence interval; FGF, fibroblast growth factor; mGFR, measured glomerular filtration rate.
a
Age at inclusion, duration of dialysis, first transplantation, living donor, delayed graft function, systolic blood pressure.