Table 3.
Potential genetic indicators of pathogenicity or human host preference.
| PB2 | PB1-F2 | HA | NA
|
NS1
|
||||
|---|---|---|---|---|---|---|---|---|
| Virus | Clade | 627Ka | #aab | # polybasic aa | antiviral sensitivityc | Δ aa 49–68d | PDZ domain ESEV | Δ aad 80–84 |
| Ck/KR/06 | 2.2 | Y | 90 | 6 | Y | Y | N | Y |
| EG/2321 | 2.2.1 | Y | 90 | 6 | Y | Y | N | Y |
| EG/4935 | 2.2.1 | Y | 90 | 6 | Y | Y | Y | Y |
| EG/3072 | 2.2.1 | Y | 90 | 6 | Y | Y | Y | Y |
| BD/5487 | 2.2.2.1 | Y | 90 | 6 | Y | Y | N | Y |
| BnSw/HK/10 | 2.3.2.1b | N | 57 | 6 | Y | Y | Y | Y |
| Dk/VN/672 | 2.3.2.1b | N | 57 | 6 | Y | Y | Y | Y |
| Dk/VN/1206 | 2.3.2.1a | N | 0 | 5 | Y | Y | Y | Y |
| Dk/VN/1232 | 2.3.2.1a | N | 90 | 5 | Y | Y | Y | Y |
| Dk/VN/0004 | 2.3.2.1c | N | 57 | 5 | Y | Y | Y | Y |
| Dk/VN/2848 | 2.3.2.1c | N | 57 | 5 | Y | Y | Y | Y |
a
Indicates presence of Lysine at position 627.
b
#aa: Number of amino acids indicating protein length
c
Molecular markers of antiviral resistance to oseltamivir, peramivir and zanamivir (CDC, 2012).
d
Δaa: Contains a deletion of amino acids at the positions shown.