Table 2.
Mean (min-max) QPI-1002 plasma PK estimates
| PK parameter | QPI-1002 dose (mg/kg) |
|||
|---|---|---|---|---|
| 0.5 | 1.5 | 5.0 | 10 | |
| n | 2 | 2 | 3 | 3 |
| Cmax (μg/ml) | 7.64 (5.7–9.6) | 12.4 (9.80–14.9) | 54.0 (22.8–89.7) | 261 (169–441) |
| AUClast (μg·hr/ml) | 2.33 (1.81–2.85) | 3.82 (3.01–4.62) | 21.1 (15.1–31.4) | 85.6 (63.6–129.4) |
| MRTlast (hr) | 0.166 (0.152–0.180) | 0.172 (0.164–0.179) | 0.174 (0.141–0.210) | 0.216 (0.184–0.244) |
| Tlast (hr) | 4 (4–4) | 6 (4–8) | 8 (8–8) | 13.4 (8–24) |
| Clast (ng/ml) | 0.335 (0.320–0.349) | 0.572 (0.250–0.894) | 0.175 (0.167–0.192) | 0.581 (0.136–1.28) |
AUClast, area under the curve from the time of dosing to the last measurable concentration; Clast, concentration corresponding to Tlast; Cmax, maximum observed plasma concentration; MRTlast, mean residence time to the last measurable concentration; Tlast, time of last measurable concentration.