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Binding motifs for triplex-forming oligonucleotides. Triplex-forming oligonucleotides (TFOs) bind in both the parallel and antiparallel direction. In the pyrimidine motif (left), TFOs bind the polypurine DNA strand in the parallel direction. In the purine motif (right), TFOs bind the polypurine DNA strand in the antiparallel direction. Corresponding canonical Watson-Crick and Hoogsteen base pair triplets are shown on below each binding motif. Adapted from [137].
