Table 1.

Demographic and clinicopathologic characteristics of 292 patients with gastric cancer

Parameters	NCT			P-value	NNCT			P-value
	Low SII <600	High SII ≥600	χ2		Low SII <600	High SII ≥600	χ2
Cases (n)	52	55			117	68
Age (years)			2.732	0.098			0.558	0.455
<57	31	24			60	31
≥57	21	31			57	37
Gender			3.098	0.078			5.119	0.024
Male	36	46			86	39
Female	16	9			31	29
BMI			0.753	0.386
<22.10	28	25
≥22.10	24	30
ABO blood type			0.451	0.930			2.880	0.411
A	16	14			32	15
B	17	19			33	27
O	14	17			37	17
AB	5	5			15	9
Radical resection			1.809	0.405			1.792	0.426
R0	30	30			100	53
R1	9	15			10	9
R2	13	10			7	6
Type of surgery			0.159	0.924*			1.078	0.583
Distal gastrectomy	30	30			79	42
Proximal gastrectomy	3	4			10	5
Total gastrectomy	19	21			28	21
Differentiation			0.042	0.979*			0.417	0.812*
Poorly differentiated	32	33			72	39
Moderately differentiated	17	19			44	28
Well differentiated	3	3			1	1
Primary tumor site			3.005	0.223*			3.918	0.141
Upper one third	3	6			12	5
Middle one third	16	23			38	32
Lower one third	33	26			67	31
Pathology			4.417	0.353*			5.418	0.144*
Normal (Tis)	7	2			0	0
Adenocarcinoma	26	35			82	44
Mucinous carcinoma	4	4			7	11
Signet ring cell carcinoma	7	5			22	11
Mixed carcinoma	8	9			6	2
Clinical TNM classification
T stage			0.068	0.795*
T3	4	5
T4	48	50
N stage			5.554	0.062*
N0	14	16
N1	33	39
N2	5	0
TNM stage			1.051	0.305
II	9	14
III	43	41
Pathologic TNM classification
T stage			5.378	0.251*			3.812	0.432*
Tis+T1	10	7			3	3
T2	0	3			15	3
T3	21	21			23	14
T4a	12	9			67	42
T4b	9	15			9	6
N stage			6.368	0.173			10.480	0.033
N0	18	14			17	10
N1	13	10			24	9
N2	5	13			32	19
N3a	10	15			36	15
N3b	6	3			8	15
Metastasis			0.403	0.525*			0.031	0.860*
M0	50	54			113	66
M1	2	1			4	2
TNM stage			1.503	0.682*			0.136	0.987*
Tis+I	9	6			5	3
II	15	16			21	11
III	26	32			87	52
IV	2	1			4	2
Total lymph nodes			0.031	0.861			1.057	0.304
<22	19	21			71	36
≥22	33	34			46	32
Positive lymph nodes			0.972	0.615			1.228	0.541
0	18	15			17	9
<5	14	14			39	18
≥5	20	26			61	41
CEA (ng/mL)			4.114	0.043			0.004	0.950
<2.72	31	22			70	41
≥2.72	21	33			47	27
CA19-9 (U/mL)			0.231	0.631			3.962	0.047
<12.12	27	26			71	31
≥12.12	25	29			46	37
Lauren classification			1.636	0.441			4.950	0.084*
Intestinal	26	31			82	44
Diffuse	18	13			4	8
Mixed	8	11			31	16
Borrmann classification			2.860	0.414*			0.195	0.978*
Borrmann I	1	0			6	3
Borrmann II	14	10			15	10
Borrmann III	29	38			83	47
Borrmann IV	8	7			13	8
Tumor size (mm)			0.092	0.761			9.329	0.002
<50	28	28			52	15
≥50	24	27			65	53

Notes:

^*Fisher’s exact test. SII is a novel systemic immune–inflammation index (SII=N×P/L), which is based on neutrophil (N), platelet (P) and lymphocyte (L) counts.

Abbreviations: BMI, body mass index; NCT, neoadjuvant chemotherapy; NNCT, non-neoadjuvant chemotherapy; CA19-9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen.