Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 15;9:165–173. doi: 10.2147/CPAA.S119295

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Singh et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Effects of PGD₂–CRTH2 signaling in asthma.

Notes: PGD₂ is predominantly released from mast cells following allergen stimulation; other cells such as eosinophils and T_H2 cells may also contribute to PGD₂ levels. Interaction of PGD₂ with CRTH2 stimulates the recruitment of T2-associated cells to the airways and release of associated cytokines, as well as eosinophil and basophil degranulation and epithelial metaplasia.

Abbreviations: CRTH2, chemoattractant receptor-homologous molecule on T helper type 2 cells; ILC2, innate lymphoid type 2 cells; IL, interleukin; PGD₂, prostaglandin D₂; T_H2, T-helper type 2 cell.