Table 1.
Proportions of lymphocytes in human placental tissue and findings ex vivo relating to outcome or lymphocyte function.
| Cell | Compartment | Approximate abundance | Comment | Reference |
|---|---|---|---|---|
| NK cells | T1 Dec | 50–70% of Dec cells | CD3-CD56+(+) | [22, 219, 220] |
| T1 Dec basalis | Low cytotoxic function | [26] | ||
| T1 Dec | ↑ Tregs by IFN-γ → IDO | [40] | ||
| T1 Dec basalis | TLR chemokine patterns | [45] | ||
|
| ||||
| B cells | Term CB | ↓ BAFF → allergy and decreased B cell maturation | [53] | |
|
| ||||
| γδ T cells | T1 Dec | 5% of CD3+ | Naive. Vδ2 skewing | [61] |
| Term UCB | 1% of lymph | [62] | ||
|
| ||||
| iNKT cells | T1 Dec | 0.5% of CD3+ versus 0.01% in PB | Th1 cytokine bias | [84] |
|
| ||||
| ILCs | T1 Dec | IL-17A and IL-22 ICS | [93] | |
BAFF: B cell activating factor; CD: cluster of differentiation; Dec: decidua; CB: cord blood; ICS: intracellular staining; IDO: indoleamine-2,3-dieoxygenase; ILC: innate lymphoid cells; lymph: lymphocytes; NK: natural killer; PB: peripheral blood; T1–3: trimester 1–3; UCB: umbilical cord blood.