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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Circ Cardiovasc Genet. 2017 Dec;10(6):e001804. doi: 10.1161/CIRCGENETICS.117.001804

Table 1.

Dosing Protocols for the Study Arms

Period Initial (d) Adjustment (d) Maintenance (d) Normalized Complexity Score
Study Arm
Fixed-dose (Control) protocol AAA Aurora (1–2) Aurora (3–7) Aurora (8–90) 1.00
Clinically guided protocol CAA IWPC Clinical (1–2) Aurora (3–7) Aurora (8–90) 1.38
PG-guided protocol PGAA IWPC PG (1–2) Aurora (3–7) Aurora (8–90) 1.93
PG-guided protocol PGPGI Modified IWPC PG (1–3) Lenzini PG (4–5) Intermountain (6–90) 2.50
PG-guided protocol PGPGA Modified IWPC PG (1–3) Lenzini PG (4–5) Aurora (6–90) 2.56

All complexity scores are normalized against the least complex warfarin therapy protocol used in this study, the Aurora best-practice fixed-dose warfarin therapy protocol. D, days; Intermountain, Intermountain Healthcare Chronic Anticoagulation Clinic Protocol; IWPC, International Warfarin Pharmacogenetics Consortium.