Table 3.
All participants: Change in markers of bone metabolism after 6 months
| Alternate day fasting (n = 21) | Daily Calorie Restriction (n = 24) | Control (n = 17) | P-values1 | ||||||
| All participants | Baseline | 6 Months | Baseline | 6 Months | Baseline | 6 Months | Diet | Time | Diet×Time |
| Osteocalcin (ng/ml) | 12±2 | 13±3 | 14±5 | 19±5 | 18±4 | 19±6 | 0.22 | 0.14 | 0.87 |
| Bone ALP (U/L) | 5±1 | 6±2 | 6±1 | 4±1 | 5±2 | 4±2 | 0.99 | 0.09 | 0.18 |
| IGF-1 (ng/ml) | 87±6 | 88±6 | 106±8 | 119±11 | 110±12 | 92±9 | 0.15 | 0.43 | <0.012 |
| CTX (ng/ml) | 0.6±0.1 | 0.8±0.2 | 1.3±0.2 | 1.3±0.2 | 1.5±0.3 | 1.4±0.2 | 0.33 | 0.36 | 0.68 |
Mean±SEM. Bone ALP: Bone alkaline phosphatase, CTX: C-terminal telopeptide of type I collagen, IGF-1: Insulin-like growth factor-1. 1Repeated measures ANOVA. 2IGF-1 increased in the CR group, with no change in the ADF or control group.