Table 7.

Baseline values and change from baseline to end of study for Aβ_1 - 42, total tau, and phospho-tau

		Baseline	Change from baseline	p value
Aβ1 - 42 (ng/L)
LMTM as add-on therapy [n = 137&66]	Mean	307	20	0.0323
	95% CI	277, 337	–3, 43
LMTM as monotherapy [n = 36&15]	Mean	377	–14	0.6698
	95% CI	310, 444	–75, 48
Total tau (ng/L)
LMTM as add-on therapy [n = 136&66]	Mean	110	22	<0.0001
	95% CI	93, 126	11, 34
LMTM as monotherapy [n = 36&15]	Mean	112	10	0.2166
	95% CI	756 148	–30, 40
Phospho-tau (ng/L)
LMTM as add-on therapy [n = 138&66]	Mean	46	3	0.4987
	95% CI	40, 53	–2, 9
LMTM as monotherapy [n = 36&15]	Mean	41	11	0.2166
	95% CI	28, 54	0, 23

Number of samples at baseline and at end of study given as monotherapy dose groups and add-on therapy dose groups pooled, [n = baseline & end].