Table 2.

Characteristics at the time of the first prAD diagnosis

	Earlier prAD	Later prAD	p-value
	(n = 1,476)	(n = 1,474)
MMSE score, mean (SD)	22.6 (4.3)	20.0 (5.9)	<0.0001
Global CDR score, mean (SD)	0.8 (0.4)	1.1 (0.6)	<0.0001
FAQ score, mean (SD)	11.6 (7.2)	17.3 (8.1)	<0.0001
Patients not categorized as dependent on FAQ, %	92.3	72.3	<0.0001
Medication use, %
AD-related medications	62.7	80.4	<0.0001
Antipsychotic agents	2.6	6.2	<0.0001

prAD, probable Alzheimer’s disease; MMSE, Mini-Mental State Examination; SD, standard deviation; CDR, Clinical Dementia Rating; FAQ, Functional Assessment Questionnaire; AD, Alzheimer’s disease. Notes: Subjects with ≥4 items at highest level (score of 3) were categorized as dependent on the FAQ. p-values were estimated using chi-square tests for categorical variables and Wilcoxon rank-sum tests for continuous variables.