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. 2017 Dec 14;12:2123–2130. doi: 10.2147/CIA.S150859

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© 2017 Shokouhi et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Illustration of the rFTC calculation.

Notes: The top plots show the FDG vectors obtained from a single subject’s FDG-PET scans at baseline, 12 months, and 24 months. The length of the vector represents the non-normalized mean FDG-PET activities in 11 cortical regions (left and right frontal lobes, posterior and anterior cingulate cortexes, occipital lobe, left and right parietal lobes, left and right temporal lobes, sub-lobar region, and mid brain). The subject’s rFTC trajectory is obtained by calculating the weighted correlation coefficients between the subject’s baseline FDG vector and those from each follow-up time point.

Abbreviations: Corr, correlation coefficient; rFTC, regional FDG time correlation coefficient; FDG, [¹⁸F]fluorodeoxyglucose; PET, positron emission tomography.