Table 1.
Baseline characteristics and clinical outcomes of patients in the two study cohorts before matching (entire cohort)
| Variable | Amylase (U/L)
|
P-values | |
|---|---|---|---|
| ≥300 (n=344) | <300 (n=120) | ||
| Age (years) | 53±18 | 43±11 | <0.001 |
| Male gender | 192 (55.8) | 89 (74.2) | <0.001 |
| Time interval before admission (days) | 1.7±0.8 | 2.1±0.8 | <0.001 |
| BMI (kg/m2) | 23.7±3.8 | 24.5±4.1 | 0.053 |
| Hypertension | 91 (26.5) | 23 (19.2) | 0.110 |
| Diabetes mellitus | 48 (14.0) | 28 (23.3) | 0.017 |
| Fatty liver | 112 (32.6) | 66 (55.0) | <0.001 |
| Alcohol consumption | 38 (11.1) | 30 (25.0) | <0.001 |
| Smoking | 70 (20.4) | 46 (38.3) | <0.001 |
| Etiology | <0.001 | ||
| Biliary | 177 (51.5) | 20 (16.7) | |
| Hypertriglyceridemia | 14 (4.1) | 13 (10.8) | |
| Alcohol | 38 (11.1) | 30 (25.0) | |
| Idiopathic | 104 (30.2) | 53 (44.2) | |
| Other | 11 (3.2) | 4 (3.3) | |
| Laboratory findings | |||
| Amylase day 1 (U/L) | 1,088 (577–2,111) | 149 (94–215) | <0.001 |
| Amylase day 2 (U/L) | 400 (204–729) | 80 (56–145) | <0.001 |
| Hematocrit (mg/dL) | 0.42±0.06 | 0.43±0.05 | 0.123 |
| Glucose (mg/dL) | 170±81 | 168±74 | 0.853 |
| BUN (mg/dL) | 14.3 (11.2–18.8) | 11.5 (9.4–14.7) | <0.001 |
| Creatinine (mg/dL) | 0.74 (0.62–0.89) | 0.74 (0.59–0.86) | 0.141 |
| Total cholesterol (mg/dL) | 175 (139–219) | 238 (192–330) | <0.001 |
| HDL-C (mg/dL) | 41 (31–51) | 33 (24–47) | 0.002 |
| LDL-C (mg/dL) | 89 (68–119) | 105 (81–132) | 0.001 |
| Triglyceride levels (mg/dL) | 95 (63–185) | 309 (160–643) | <0.001 |
| Outcomes | |||
| Severity of acute pancreatitis | 0.241 | ||
| Mild | 254 (73.8) | 94 (78.3) | |
| Moderately severe | 48 (14.0) | 18 (15.0) | |
| Severe | 42 (12.2) | 8 (6.7) | |
| Median hospital stay (days) | 10 (7–14.5) | 9 (7–12) | 0.074 |
| Death | 7 (2.0) | 1 (0.8) | 0.384 |
Note: Data are presented as mean ± standard deviation, or numbers (%), or median (25th–75th percentile), as appropriate.
Abbreviations: BMI, body mass index; BUN, blood urea nitrogen; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.