Table 3.
HRs for CVD events association with the plasma levels of fibrinogen (low, middle and high)
| 1 SD fibrinogen increase | p-Value | |||
| Crude | 1.25 (1.06 to 1.48) | 0.010 | ||
| Model 1 | 1.26 (1.06 to 1.49) | 0.008 | ||
| Model 2 | 1.25 (1.05 to 1.49) | 0.013 | ||
| Model 3 | 1.36 (1.07 to 1.72) | 0.011 | ||
| Model 4 | 1.34 (1.05 to 1.71) | 0.017 | ||
| Model 5 | 1.30 (1.02 to 1.66) | 0.037 | ||
| Model | HR (95% CI) | p for trend | ||
| Low (Reference) | Middle | High | ||
| Crude | 1.00 | 1.10 (0.64 to 1.91) | 1.99 (1.21 to 3.26) | 0.008 |
| Model 1 | 1.00 | 1.10 (0.64 to 1.92) | 2.00 (1.22 to 3.30) | 0.007 |
| Model 2 | 1.00 | 1.09 (0.63 to 1.89) | 1.97 (1.19 to 3.26) | 0.009 |
| Model 3 | 1.00 | 1.14 (0.65 to 2.00) | 2.15 (1.22 to 3.80) | 0.012 |
| Model 4 | 1.00 | 1.23 (0.69 to 2.19) | 2.10 (1.16 to 3.80) | 0.031 |
| Model 5 | 1.00 | 1.23 (0.69 to 2.20) | 2.02 (1.11 to 3.68) | 0.049 |
Model 1: adjusted for sex and age; Model 2: Model 1+ total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, hypertension and smoking; Model 3: Model 2+ triglycerides, hs-CRP, and HbA1c; Model 4: Model 3+uric acid, body mass index and family history of CVD and Model 5: Model 4+left ventricle ejection fraction.
CVD, cardiovascular disease; HbA1c, glycosylated haemoglobin type A1C; hs-CRP, high sensitivity C-reactive protein.