Execution times for different aligners/options as number of input sequences is changed. The color scheme is the same as in Figures 1 and 2 (Clustal Omega red, MAFFT blue, MUSCLE green, ClustalW2 orange). Solid bullets are used for default options: blue triangle for MAFFT L‐INS‐i, blue box for MAFFT PartTree, green box for fast MUSCLE option, orange circles for ClustalW2. Error bars indicate times for short (bottom), medium (middle) and long (top) protein domains. Solid lines connecting middle points are used to guide the eye