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. 2017 Nov 22;13:1744806917746564. doi: 10.1177/1744806917746564

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — T10 dose dependently inhibited SNL-induced mechanical allodynia of the ipsilateral hind paw. (a) The analgesia effects of different doses of i.t. T10. (b) The AUCs for the different groups were calculated for statistical analysis. (c–d) The dose-effect and log (dose)-effect curves for the analgesic effects in attenuating SNL-induced mechanical allodynia after i.t. saline and T10, respectively. ⋆P < 0.001, SNL saline group versus sham saline group; *P < 0.05, **P < 0.01, and ***P < 0.001, SNL-T10 groups versus SNL saline group; ^#P < 0.05, SNL-T10 (10 µg/kg) versus SNL-T10 (3 µg/kg) group; ♦♦♦P < 0.001, SNL-T10 (30 µg/kg) versus SNL-T10 (10 µg/kg) group; ★★★P < 0.001, SNL-T10 (30 µg/kg) versus SNL-T10 (3 µg/kg) group. AUC: area under curve; SNL: spinal nerve ligation; ED₅₀: effective dose 50.