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. 2017 Nov 22;13:1744806917746564. doi: 10.1177/1744806917746564

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — MK-801 dose dependently inhibited SNL-induced mechanical allodynia of the ipsilateral hind paw. (a) The analgesia effects of different doses of i.t. MK-801. (b) The AUCs for the different groups were calculated to perform a statistical analysis. (c–d) The dose-effect and log (dose)-effect curves for the analgesic effects in attenuating SNL-induced mechanical allodynia after i.t. saline and MK-801, respectively. ⋆P < 0.001, SNL saline group versus sham saline group; *P < 0.05, **P < 0.01, and ***P < 0.001, SNL-MK-801 groups versus SNL saline group; ^##P < 0.01, SNL-MK-801 (30 µg/kg) versus SNL-MK-801 (10 µg/kg) group; ♦P < 0.05, SNL-MK-801 (90 µg/kg) versus SNL-MK-801 (30 µg/kg) group; ★★★P < 0.001, SNL-MK-801 (90 µg/kg) versus SNL-MK-801 (10 µg/kg) group. AUC: area under curve; SNL: spinal nerve ligation; ED₅₀: effective dose 50.