Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 22;13:1744806917746564. doi: 10.1177/1744806917746564

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 4. — Combination treatment of T10 or MK-801 with different ratios. (a, b, and c) The analgesia effect of different volumes of i.t. T10 or MK-801 with different dose ratios. (a′, b′, and c′) The AUCs for different groups were calculated to perform statistical analysis. (a′′, b′′, and c′′) The dose-effect and log (dose)-effect curves for the analgesic effects in attenuating SNL-induced mechanical allodynia after i.t. saline, T10 and/or MK-801. (a′′′, b′′′, and c′′′) The iosobolograms for the combination analgesia. ⋆P < 0.001, SNL saline group versus sham saline group; *P < 0.05, **P < 0.01, SNL-T+M groups versus SNL saline group; ^#P < 0.05, SNL-T (10 µg/kg)+M (30 µg/kg) groups versus SNL-T (3 µg/kg)+M (10 µg/kg) groups; ♦♦P < 0.01 and ♦♦♦P < 0.001, SNL-T (30 µg/kg)+M (90 µg/kg) groups versus SNL-T (10 µg/kg)+M (30 µg/kg) groups; ★★★P < 0.001, SNL-T (30 µg/kg)+M (90 µg/kg) groups versus SNL-T (3 µg/kg)+M (10 µg/kg) groups. AUC: area under curve; SNL: spinal nerve ligation; ED₅₀: effective dose 50.