Table 1.

Overview of the longitudinal assessments during risk periods and following onset of bipolar disorder in the four substudies of the BIO study

Course	Healthy first-generation relatives	First episode	Remission	First relapse	Remission	Second relapse	Others
BIO-1	x	x	x	x	x	x	x
BIO-2	x	x	x	x	x	x	x
BIO-3	x		x		x		x
BIO-4	x	x	x	x	x	x	x

BIO-1: Peripheral blood-based biomarker in bipolar disorder.

BIO-2: Smartphone-based electronic biomarker in bipolar disorder.

BIO-3: Neurocognitive and brain imaging signatures in bipolar disorder.

BIO-4: At risk or prodromal phase for bipolar disorder.

BIO, Bipolar Illness Onset study.