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. 2017 Jul 2;7(6):e014581. doi: 10.1136/bmjopen-2016-014581

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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Paired forest plots for anti-TNF antibody levels for predicting loss of response or failure to regain response to infliximab (top) and adalimumab (bottom). CDAI, Crohn’s Disease Activity Index score; CRP, C reactive protein level; HBI, Harvey Bradshaw Index score; HMSA, homogeneous mobility shift assay; LR, patients with loss of response; PJ, physicians’ judgement; PJ BM, physicians’ judgement and biological measure; POP, study patient population; R, patients with response; RES, criterion for determining clinical response; RIA, radioimmunoassay; RS, restart anti-TNF after drug holiday; SA, switch anti-TNF; ST, stop anti-TNF therapy; TC, treatment change; UC, unclear.