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. 2017 Jul 2;7(6):e014581. doi: 10.1136/bmjopen-2016-014581

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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Paired forest plots for trough anti-tumour necrosis factor levels for predicting loss of response or failure to regain response to infliximab (top) and adalimumab (bottom). CDAI, Crohn’s Disease Activity Index score; CRP, C reactive protein level; HBI, Harvey Bradshaw Index score; HMSA, homogeneous mobility shift assay; LR, patients with loss of response; MH, mucosal healing; PJ, physicians’ judgement; PJ BM, physicians’ judgement and biological measure; POP, study patient population; R, patients with response; RES, criterion for determining clinical response; RIA, radioimmunoassay; UC, unclear.