Table 3.
Estimated Means for the Primary and Secondary Outcomes by Group
| Variable | Mean (95% CI) | Group Comparison | ||
|---|---|---|---|---|
| Placebo Plus CBT | D-Cycloserine Plus CBT | t Statistic | P Value | |
| CY-BOCS | ||||
| Randomization | 22.93 (21.11–24.74) | 24.33 (22.48–26.18) | 1.01 | .32 |
| Visit 7 | 21.05 (19.35–22.74) | 22.26 (20.54–23.98) | 0.85 | .40 |
| Visit 8 | 19.17 (17.47–20.86) | 20.19 (18.47–21.91) | 0.62 | .54 |
| Visit 9 | 17.29 (15.48–19.10) | 18.12 (16.27–19.97) | 0.36 | .72 |
| Posttreatment | 13.53 (11.22–15.85) | 13.98 (11.60–16.36) | −0.06 | .95 |
| CGI-Severity | ||||
| Randomization | 3.43 (3.17–3.69) | 3.67 (3.41–3.94) | 1.35 | .18 |
| Visit 7 | 3.19 (2.94–3.44) | 3.39 (3.14–3.65) | 1.12 | .26 |
| Visit 8 | 2.95 (2.69–3.20) | 3.12 (2.86–3.37) | 0.82 | .41 |
| Visit 9 | 2.71 (2.44–2.98) | 2.84 (2.56–3.11) | 0.50 | .62 |
| Posttreatment | 2.23 (1.89–2.56) | 2.28 (1.94–2.63) | −0.04 | .97 |
| CY-BOCS Compulsions | ||||
| Randomization | 12.05 (11.10–13.00) | 12.67 (11.71–13.62) | 0.85 | .40 |
| Visit 7 | 11.05 (10.16–11.93) | 11.59 (10.71–12.48) | 0.70 | .49 |
| Visit 8 | 10.04 (9.17–10.92) | 10.53 (9.65–11.41) | 0.49 | .63 |
| Visit 9 | 9.04 (8.10–9.98) | 9.46 (8.51–10.40) | 0.25 | .80 |
| Posttreatment | 7.03 (5.83–8.23) | 7.32 (6.09–8.54) | −0.13 | .90 |
| CY-BOCS Obsessions | ||||
| Randomization | 11.20 (10.22–12.19) | 11.76 (10.78–12.75) | 0.38 | .70 |
| Visit 7 | 10.29 (9.39–11.21) | 10.74 (9.86–11.64) | 0.20 | .84 |
| Visit 8 | 9.39 (8.49–10.30) | 9.71 (8.80–10.61) | −0.01 | .99 |
| Visit 9 | 8.49 (7.53–9.46) | 8.68 (7.70–9.66) | −0.20 | .84 |
| Posttreatment | 6.69 (5.45–7.94) | 6.63 (5.36–7.90) | −0.47 | .64 |
| CDRS | ||||
| Randomization | 46.15 (42.69–49.61) | 46.59 (42.96–50.23) | −0.88 | .38 |
| Visit 8 | 43.51 (40.47–46.56) | 46.13 (42.96–49.29) | −0.03 | .98 |
| Posttreatment | 39.56 (35.87–43.25) | 45.42 (41.61–49.24) | 1.16 | .25 |
| MASC | ||||
| Randomization | 39.53 (32.35–46.72) | 47.39 (40.07–54.72) | 1.42 | .16 |
| Visit 8 | 36.62 (30.13–43.11) | 44.59 (37.95–51.24) | 1.67 | .10 |
| Posttreatment | 32.24 (25.40–39.08) | 40.40 (33.33–47.47) | 1.73 | .09 |
| COIS-P | ||||
| Randomization | 14.88 (11.68–18.07) | 16.28 (13.05–19.50) | −0.89 | .38 |
| Visit 8 | 12.58 (9.58–15.58) | 13.74 (10.71–16.77) | −0.75 | .45 |
| Posttreatment | 9.14 (5.86–12.41) | 9.94 (6.64–13.24) | −0.42 | .67 |
Abbreviations: CBT, cognitive behavior therapy; CDRS, Children’s Depression Rating Scale; CGI-Severity, Clinical Global Impressions-Severity; COIS-P, Children’s Obsessive- Compulsive Impact Scale-Parent Version; CY-BOCS, Children’s Yale-Brown Obsessive Compulsive Scale; MASC, Multidimensional Anxiety Scale for Children.