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Cobinamide dose-dependently prevents H2S intoxication. (A) H2S exposure paradigm in a whole-body inhalation chamber for 7 days. (B) Weight loss, (C) mortality, (D) seizure activity, and (E) knockdown following H2S exposure. * P < 0.05; slopes are significantly different from H2S saline group. (F) Rotarod behavior testing post 2, 4, and 6 H2S exposures. ** P < 0.01 versus H2S/saline group.
