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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Ann N Y Acad Sci. 2017 Nov;1408(1):61–78. doi: 10.1111/nyas.13559

Figure 4.

Figure 4

Cobinamide (100 mg/kg) prevents oxidative stress and mitochondrial dysfunction induced by H2S exposure. Animals exposed to H2S and treated with Cob have less 4-HNE production in the inferior colliculus than untreated animals. (A) Representative photomicrographs of the inferior colliculus demonstrate similar amounts of 4-HNE in controls and in animals exposed to H2S and given Cob treatment, compared with animals exposed to H2S alone (arrows). (B) Bad expression induced by H2S with and without Cob treatment. * P < 0.05 versus H2S/saline group. Representative photomicrographs of the inferior colliculus (4HNE immunohistochemical staining).