Table 1.
Modified functional observational battery for evaluation of clinical signs during H2S exposure in the inhalation chamber.
| Measure | Breathing air + saline | H2S + saline | H2S + cobinamide (100 mg/kg) |
|---|---|---|---|
|
| |||
| Autonomic | |||
| Lacrimation | No | Present | No |
| Salivation | No | Present | No |
| Urination/defecation | Normal | Increased | No |
| Convulsions | |||
| Tonic movements | No | Mild | No |
| Clonic movements | No | Severe | Mild |
| Paddling feet | No | Severe | Mild |
| General measures | |||
| Piloerection | No | Present | No |
| Body posture | Normal | Hunched | Hunched |
| Dyspnea | No | Present | Present |
| Gait | |||
| Hindlimbs splayed | No | Present | No |
| Ataxia | No | Severe | Mild |
| Unable to support weight | No | Present | No |
| Righting reflex | No | Affected | Mild |
| Knockdown | No | Severe | Mild |