Table 2.

Risk of aortic stenosis with sibling history of AS.

		Model 1		Model 2		Model 3
	N	HR	95% CI	HR	95% CI	HR	95% CI
Sibling history of AS	650	4.18	2.73–6.39	4.11	2.68–6.30	3.41	2.23–5.21
Male gender		2.04	1.39–2.98	2.04	1.39–2.99	1.62	1.11–2.37
Birth year		0.94	0.66–1.33	0.94	0.66–1.33	0.96	0.68–1.35
Family size				1.02	0.71–1.45	1.01	0.71–1.44
Medical history
COPD						1.74	1.17–2.61
Diabetes						1.55	1.05–2.30
Obesity						1.08	0.68–1.70
Hypertension						2.95	2.00–4.33
Atrial fibrillation						3.25	2.20–4.81
Coronary heart disease						2.99	2.03–4.41

Model 1: adjusted for gender and birth year. Model 2: adjusted for gender, birth year and family size. Model 3: full model (adjustments in model 2 combined with comorbidities).

AS: Aortic stenosis. COPD: Chronic obstructive pulmonary disease.

N: Number of AS cases.