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. 2017 Dec 18;12(12):e0189536. doi: 10.1371/journal.pone.0189536

Fig 2. HTS inhibits the expression of chemokines and cytokines that regulate immune cell trafficking and polarization.

Fig 2

SAECS in P4 were treated with cytomix in the presence and absence of HTS for 4 and 8hrs, and RNA isolated for qPCR analysis. Validation of the RNAseq shows that (a) chemokines that affect T-cell, Dendritic cell, and NK cell interaction/migration, (b) monocyte trafficking, (c) IL-1 family cytokines, and Th17 response are all increased due to cytokine treatment, and attenuated by HTS; whereas HTS-specific genes such as IL-11 are upregulated in response to HTS. (*p< 0.05; **p< 0.01; ***p< 0.001; ****p< 0.0001).