Table 1. Clinical, familial and genetic data of 50 patients with advanced or end stage cardiomyopathy.

Patient ID	Gender	Age at diagnosis (Years)	Treatment	NYHA*/Task Force classification†	Age at HTxa/VADb	Family history‡	Affected Genes (ACMG class)
DCM-01	m	1	VAD, HTx	IV	13a	Sporadic§	MYH7 (4), MYL2 (4)
DCM-02	m	31	pre HTxII	III	-	Sporadic	TTN (3)
DCM-03	m	68	ICD, VAD	III	69b	Son with DCM	TTN (4), DSC2 (2), TTN (3)
DCM-04	m	30	HTx	IV	62a	Mother (61y) died from DCM	TTN (4), DSP (3)
DCM-05	m	11	HTx	IV	14	Older brother with DCM and HTx	TNNC1 (4), TNNC1 (3)
DCM-06	m	< 1	VAD, HTx	IV	<1a	Sporadic	TTN (3)
DCM-07	m	35	ICD, VAD, HTx	IV	47a	Cousin with HTx, sister with suspicion of DCM, father and brother died from heart disease, sister with heart disease	LMNA (5)
DCM-08	m	23	VAD, HTx	IV	23a	Father with DCM	TTN (3)
DCM-09	f	41	ICD, AMB	II#,**	-	SCD of father (40y), brother died from heart disease (23y)	DES (5), TTN (3)
DCM-10	m	33	ICD, HTX	IV	37	Mother and aunt with HTx, brother and niece with DCM	DSP (2)
DCM-11	m	36	ICD, HTx	III-IV	48a	Two cousins died from SCD	DES (4)
DCM-12	m	18	ICD, VAD	III-IV	29b	Sporadic	TTN (4), TNNT2 (3)
DCM-13	m	39	pre HTxII	I#,**	-	Father with DCM and HTx	LMNA (4), TTN (4)
DCM-14	m	60	ICD, HTx	III	63a	Mother and two brothers died from heart disease, sister with DCM and HTx	RBM20 (4), DSP (3)
DCM-15	m	32	HTx	III	40a	Son with DCM and HTx, sister with DCM	RBM20 (5), TTN (3)
DCM-16	f	20	ICD, VAD	III-IV	32b	Sporadic	TTN (4), TTN (3)
DCM-17	m	14	ICD,HTx	III	59	Father and paternal uncle with SCD	DES (5)
DCM-18	f	n.a	ICD, HTx	IV	52a	Monozygotic twin sister (45y) died from heart disease	LMNA (5)
DCM-19	m	5	ICD, VAD	IV	22b	Sporadic	NEXN (4), MYH7 (4)
DCM-20	m	35	ICD, pre HTx	II-III	-	Father with DCM	TTN (4), DSP (3)
DCM-21	f	n.a	ICD, pre HTx	II#,**	-	Father died from DCM, deceased brother with VAD, son and daughter with heart disease	TTN (3)
DCM-22	f	59	pre HTxII	II#,**	-	Brother with HTx, another brother with VAD	TTN (4)
DCM-23	f	n.a.	HTx	IV	14a	SCD of 2 brothers in childhood, 2 siblings with DCM and HTx in adolescent age	PKP2 (4), LAMA4 (2)
DCM-24	f	30	VAD	IV	31b	Sporadic	TTN (3)
DCM-25	m	40	ICD, pre HTx	II-III	-	SCD of 3 maternal uncles, son with DCM	Unknown
DCM-26	f	n.a	HTx	IV	16a	Sporadic	Unknown
DCM-27	m	38	VAD, HTx	IV	53a	Father died from DCM (43y), brother and sister with heart disease	Unknown
DCM-28	m	37	ICD, VAD, HTx	IV	52a	SCD of maternal grandmother (60y)	Unknown
DCM-29	m	31	HTx	IV	42a	Paternal grandfather (51y) and father (46y) deceased from heart disease	Unknown
DCM-30	m	36	ICD, pre HTx	II**	-	Sporadic	Unknown
RCM-01	f	12	VAD, HTx	IV	13a	Sporadic	MYL3 (3)
RCM-02	m	< 1	VAD	IV	<1b	Sporadic	TNNI3 (4)
RCM-03	m	19	HTx	IV	12a	Mother (42y) with muscular dystrophy died from heart disease	CRYAB (5)
ARVC-01	m	14	ICD	DD††**		Sporadic	PKP2 (5)
ARVC-02	m	35	ICD, HTx	DD	36a	SCD of father, brother with heart disease	MYH7 (3)
ARVC-03	m	67	ICD	PD		Sporadic	PRKAG2 (3)
ARVC-04	f	35	ICD, TAH	DD	55b	SCD of maternal grandmother and uncle, sister with DCM	PLN (5), MYH6 (3), TTN (2)
ARVC-05	f	45	ICD, HTx	DD	47a	Maternal grandfather with SCD	LMNA (4), PKP2 (3)
ARVC-06	f	21	ICD, HTx	DD	32a	ARVC with SCD of father and brother	PKP2 (5), PKP2 (3), RYR2 (3), TTN (3)
ARVC-07	m	40	ICD, HTx	BL	62a	Paternal great-grandfather and father with heart disease and premature death	DES (3)
ARVC-08	m	16	ICD, HTx	BL††	21a	Sporadic	Unknown
ARVC-09	f	42	VAD	PD	45b	Sporadic	Unknown
ARVC-10	f	n.a	ICD, HTx	DD	46a	Two maternal great-uncles with SCD	Unknown

Abbreviations

a = age at HTx, ACMG class 2 = likely benign, ACMG class 3 = variant of uncertain significance, ACMG class 4 = likely pathogenic, ACMG class 5 = pathogenic, AMB = ambulatory, ARVC = arrhythmogenic right ventricular cardiomyopathy

b = age at VAD, DCM = dilated cardiomyopathy; f = female, FS = fractional shortening, HTx = heart transplantation, ICD = implantable cardioverter defibrillator, ID = identification, m = male, n.a. = not available, RCM = restrictive cardiomyopathy, SCD = sudden cardiac death, TAH = total artificial heart, VAD = ventricular assist device; y = year(s).

^*New York Heart Association functional classification of heart failure before VAD or HTx, respectively.

^†Classification according Task Force Criteria [13].

^‡Familial disposition for cardiomyopathy due to pedigree analysis and anecdotal evidence.

^§Sporadic = isolated cases without family history.

^IITreated medically.

^#Progressive cardiomyopathy with familial disposition due to pedigree analysis or anecdotal evidence, respectively.

**Not yet listed for HTx but in the long term surveillance program.

^†† Classification according to Task Force Criteria [13] and consideration of the modified pediatric criteria [14]. For pedigrees see S2 Fig.