Table 2.
Liver tissues morphological anomalies | Control | 96h | 7th | 14th | 21st | 28th | 35th |
---|---|---|---|---|---|---|---|
Nuclear degeneration | − | ++ | − | − | − | − | − |
Vacuolization | − | ++ | − | + | + | + | − |
Cellular edema | − | ++ | − | − | + | + | + |
Increased sinusoidal space | − | ++ | + | + | + | + | + |
Necrosis | − | + | − | − | − | − | + |
Altered hepatocyte | − | + | − | + | + | + | + |
Note: The anomalies visible in the liver morphology were divided based on the severity into three grades (−) no anomalies; (+) anomalies in <20% of the fields; (++) anomalies in <20–60% of the fields.