Table 4. Estimation of the fraction of non-synonymous SNVs that lead to a phenotype.
Table 4—source data 1. Estimation of the fraction of SNVs and Indels that leads to a phenotype.
elife-27469-table4-data1.xlsx (35.1KB, xlsx)
DOI: 10.7554/eLife.27469.011
Table 4—source data 2. Estimated mutation rates.
elife-27469-table4-data2.xlsx (28.2KB, xlsx)
DOI: 10.7554/eLife.27469.012
| ura4 | ura5 | Total | ||
| (265 Aa) | (216 Aa) | (481 Aa) | ||
| Potential SNVs | Synonymous | 530 (0.22) | 443 (0.23) | 973 (0.22) |
| Non-synonymous | 1739 (0.73) | 1405 (0.72) | 3144 (0.73) | |
| STOPs | 116 (0.05) | 96 (0.05) | 212 (0.05) | |
| Observed SNVs | Synonymous | 3 (0.03) | 2 (0.03) | 5 (0.03) |
| Non-synonymous | 74 (0.69) | 58 (0.73) | 132 (0.71) | |
| STOPs | 29 (0.27) | 19 (0.24) | 48 (0.26) | |
| Non-coding | 1 (0.01) | 0 (0.00) | 1 (0.00) | |
| Different mutations per Aa | (41,13,3) | (23,7,5,0,0,1) | (64,20,8,0,0,1) | |
| Independent identical mutations per non-syn SNV | (64,9,1) | (41,11,2,1,1,0,1, 0,1) | (105,20,3,1,1,0,1, 0,1) | |
| Method 1 | Essential Aa (ML) | 124 | 54 | 170 |
| (Essential Aa) | [CI 95%] | [93,202] | [43,81] | [140,228] |
| f | 0.47 | 0.25 | 0.35 | |
| [CI 95%] | [0.35,0.76] | [0.20,0.38] | [0.29,0.47] | |
| Method 2 | Essential NS (ML) | 296 | 88 | 276 |
| (Non-Syn) | [CI 95%] | [195,394] | [73,118] | [228,362] |
| f | 0.17 | 0.06 | 0.09 | |
| [CI 95%] | [0.11,0.23] | [0.05,0.08] | [0.07,0.12] | |
| Method 3 | # STOPs among all potentials STOPs | 0.25 | 0.20 | 0.23 |
| (LM08) | f | 0.17 | 0.21 | 0.19 |