Skip to main content
. 2017 Dec 18;6:e28070. doi: 10.7554/eLife.28070

Figure 4. Autosomes change in a cohesive manner and coevolution of X and A.

(A) The density plot of autosome copy number among 620 cell lines shows peaks at 2 and 3 per autosome. (B-C) The observed distributions of gain in copy number among autosomes in two HeLa sublines. The expected Poisson distributions are also given for sublines with different means (λ = 10/13, 16/13; see text). (D) The percentages of C(Xa:A) types among the 620 cell lines.

Figure 4.

Figure 4—figure supplement 1. Both the ancestral and sub-clonal HeLa population have 55–75 chromosomes centering around the triploid count of 69.

Figure 4—figure supplement 1.

(B) The composite distribution of the five lines with λ < 1. And the comparison to Poisson distribution.
Figure 4—figure supplement 2. The frequency spectrum of C(Xa:A) across all male and female cancerous cell lines.

Figure 4—figure supplement 2.

The median values for copy numbers on autosomes and X chromosome were used to calculate C(Xa:A). The proportion of cell lines within a bin (0.1) was plotted as the Y-axis. The discrete peaks denote the four major genotypes (X:3A; X:2A; 2X:3A; 2X:2A).