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. Author manuscript; available in PMC: 2017 Dec 18.
Published in final edited form as: Nature. 2017 Mar 29;544(7650):316–321. doi: 10.1038/nature21720

Extended Data Figure 7. RA-dependent homeostatic plasticity and LTD are normal in Syt1,7 double-deficient neurons.

Extended Data Figure 7

a, Representative traces of evoked AMPAR- and NMDAR-mediated EPSCs in dual recordings of infected Cre and uninfected adjacent neurons in the same cultured hippocampal slice that had been incubated for 36 hrs in DMSO and CNQX.

b, Summary graph of AMPAR-/NMDAR-ESPC ratios calculated from the EPSCs monitored in a.

c & d, Scatter plots of individual dual recordings of AMPAR- and NMDAR-EPSCs in Syt1,7 double KO and control neurons in slices that had been incubated DMSO or CNQX.

e, Syt1,7 DKD does not alter NMDAR-dependent LTD (left, representative traces and time course of LTD induced; center and right, cumulative frequency plots and summary graphs of the LTD magnitude).

All data are means ± SEM; numbers in bars indicate number of neurons/mice analyzed. Statistical significance was assessed by Mann-Whitney U test comparing test conditions to control (**, p<0.01).