Figure 2. Hazard Ratio (HR) and 95% Confidence Interval (CI) for Global Index Events (GIE) and Components by Vaginal Estrogen (VE) Use Overall and by Hysterectomy Status1.
1 VE includes vaginal cream or vaginal tablet. VE and hysterectomy status were included in the model as time-varying covariates. Global Index Event (GIE) is defined as time to first coronary heart disease, breast cancer, stroke, pulmonary embolism, hip fractures, colorectal cancer, endometrial cancer, or death. Analysis for endometrial cancer was not conducted in participants with hysterectomy or in the overall analytic sample. Rate are crude rates per 1000 person-years (N= 45,663). Model 1 is adjusted for age, education, past estrogen use, history of cancer before study baseline, history of cardiovascular disease before study baseline, history of deep vein thrombosis or pulmonary embolism before study baseline. Model for overall analytic sample also includes hysterectomy status. (N=45,251). Model 2 was adjusted for variables in Model 1 and race/ethnicity, baseline body mass index, baseline diagnosis of diabetes, baseline physical activity (total MET-hours/week), hypertension, Gail breast cancer risk score, fracture after age 55 prior to study enrollment, smoking, income, and alcohol use (servings/week) (N=36,629)