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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Neurochem. 2017 Nov 20;144(1):7–34. doi: 10.1111/jnc.14242

Figure 4. A summary of the role of O-GlcNAc in regulating essential brain functions.

Figure 4

UDP-GlcNAc, the end product of the nutrient-sensitive HBP, is dynamically used by OGT to catalyze the addition of O-GlcNAc to substrate proteins. This cyclic modification is coordinately regulated with other PTMs such as phosphorylation to regulate the required intricacies of cellular processes. Deregulation of PTMs including O-GlcNAc leads to several pathologies that are associated with neurodegeneration. Methods for detecting O-GlcNAc and understanding its role in these pathologies continue to improve providing a strong foundation for considering targeted therapeutics based on individual or global protein O-GlcNAcylation and the activities of OGT and OGA.