Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Downstream processing after binding of NRG3 to ERBB4 receptors. After binding ERBB4 is activated by autophosphorylation and phosphorylates other targets resulting in activation of ADAM17 which sheds its extracellular domain and Gamma-secretase which releases its intracellular domain. The latter translocates to the nucleus where it participates in transcriptional regulation.
