Table 3.
Disability-adjusted life years (DALY) lost and Quality-adjusted life years (QALY) gained in endovascular versus alteplase-only groups calculated with and without age-weighting and discounting.
| Median years (IQR) endovascular versus alteplase-only |
p-Value |
Worst-case ICER (US dollars) | ||
|---|---|---|---|---|
| Unadjusted | Adjusted for age and baseline NIHSS | |||
| DALY lost | ||||
| Not discounted not age-weighted | 5.5 (3.2–8.7) versus 8.9 (4.7–13.8) (mean difference 2.72) | 0.04 | 0.02 | $3,509 |
| Discounted not age-weighted | 3.2 (1.9–6.2) versus 6.3 (2.9–10.5) (mean difference 2.34) | 0.02 | 0.02 | $4,079 |
| Not discounted age-weighted | 2.3 (1.6–5.0) versus 4.1 (2.2–7.5) (mean difference 1.45) | 0.07 | 0.02 | $6,583 |
| Discounted age-weighted | 2.0 (0.94–3.6) versus 3.5 (1.6–5.8) (mean difference 1.27) | 0.03 | 0.02 | $7,516 |
| QALY gained | ||||
| Not discounted | 9.3 (4.2–13.1) versus 4.9 (0.3–8.3) (mean difference 3.29) | 0.01 | 0.03 | $2,901 |
| Discounted | 7.5 (2.7–10.2) versus 4.0 (0.3–6.9) (mean difference 2.50) | 0.01 | 0.03 | $3,818 |
Worst-case incremental cost-effectiveness ratios (ICER) based on upper 95% confidence interval for endovascular cost and lower 95% confidence interval for alteplase-only cost.