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. 2017 Dec 18;7:17702. doi: 10.1038/s41598-017-17377-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immuno-electron microscopy. (A) Mature excitatory and inhibitory synapses show absence of GAP-43 signal in the cortex of a Non-CD rat 4 months after PTZ induced acute seizure. The left arrow shows an excitatory synapse with spherical vesicles and asymmetric postsynaptic density. The right arrow shoes an inhibitory synapse with flattened vesicles and symmetric postsynaptic density. (B) Axon terminal within the cortex of a CD rat 4 months after PTZ induced acute seizure. Arrows show GAP-43 (10 nm gold). The star (*) shows spherical vesicles within the axon suggestive of excitatory output as described in Gray, 1959. (C) Capillary lumen from a CD animal with spontaneous seizures shows GAP-43 positive staining. Scale bars = 100 nm. Sample sizes: CD + PTZ n = 2, Non-CD + PTZ n = 2.