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. 2017 Dec 18;7:17705. doi: 10.1038/s41598-017-17672-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Definition of the Capsid NLS:IMPα interface. (A) Full, Core and Min-NLS sequences (single letter amino acid code). (B) Docked Core-NLS (brown) aligned on the full NLS (green) from the crystal structure of the VEEV NLS bound to the binding site of IMPα (grey) using Maestro (Schrodinger) and the PDB 3VE6 coordinates. Red and blue represent oxygen and nitrogen atoms respectively. (C) Docked Min-NLS (purple) aligned on the full NLS within the crystal structure of the VEEV NLS bound to the binding site of IMPα as per B.