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. 2017 Dec 18;7:17705. doi: 10.1038/s41598-017-17672-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antiviral activity of 1111684 is through targeting the IMPα/β1:C interaction. Vero cells were pretreated for 2 h with Mifepristone (10 μM), Ivermectin (1 μM), 1111684 (10 μM), or a DMSO only control. Supernatants were removed, and virus added (WT or CM, MOI 0.1). After 1 h, the medium was replaced with medium containing compound. After 16 h, supernatants were collected and plaque assays performed to determine viral titers (using Vero or BHK.J cells for TC83-WT or TC83-CM virus, respectively). Data represent mean ± SD (n = 3). *p < 0.05 compared to DMSO.