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. 2017 Dec 18;7:17705. doi: 10.1038/s41598-017-17672-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compounds identified by in silico screening inhibit IMPα/β1:C binding. Pre-dimerized recombinant IMPα/β1 heterodimer (15 nM) and capsid (30 nM) were incubated together in the presence of 10 µM of each compound, and protein binding measured by AlphaScreen assay as described in Materials and Methods. The percentage inhibition of binding effected by each compound above background was standardized to DMSO-only positive control wells. Histogram shows the distribution of activity of all 84 compounds tested.