Figure 9.
Docking of the four lead compounds to IMPα. Top: lead compounds (green) superimposed on the Core-NLS (yellow, conformation from PDB 3VE6). Bottom: IMPα binding pocket (grey) interactions with the compounds. Key residues highlighted are W72, W114 and W161, which participate in hydrophobic interactions (yellow); D122, which participates in salt bridge interactions (blue) and N76, N118 and N158, which participate in hydrogen bonding (red).