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. 2017 Dec 18;7:17705. doi: 10.1038/s41598-017-17672-9

Figure 9.

Figure 9

Docking of the four lead compounds to IMPα. Top: lead compounds (green) superimposed on the Core-NLS (yellow, conformation from PDB 3VE6). Bottom: IMPα binding pocket (grey) interactions with the compounds. Key residues highlighted are W72, W114 and W161, which participate in hydrophobic interactions (yellow); D122, which participates in salt bridge interactions (blue) and N76, N118 and N158, which participate in hydrogen bonding (red).