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. 2017 Dec 18;7:17705. doi: 10.1038/s41598-017-17672-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Docking of the four lead compounds to IMPα. Top: lead compounds (green) superimposed on the Core-NLS (yellow, conformation from PDB 3VE6). Bottom: IMPα binding pocket (grey) interactions with the compounds. Key residues highlighted are W72, W114 and W161, which participate in hydrophobic interactions (yellow); D122, which participates in salt bridge interactions (blue) and N76, N118 and N158, which participate in hydrogen bonding (red).

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