Table 2.

Fold regulation comparison and p-value for genes within the human Wnt signaling and related pathways in human astrocytes under hypoxia with or without hypothermic intervention (a full list of all the investigated genes is provided in Supplementary Tables 2,3).

Unigene ID	Gene symbol	Fold change	p-value
Hs.213424	SFRP1	−6.3451	0.005
Hs.282410	CALM1	−6.2696	<0.001
Hs.121540	WNT10A	−5.7345	<0.001
Hs.584775	LRP6	−4.0256	0.011
Hs.149504	WNT9A	−4.0151	<0.001
Hs.94234	FZD1	−3.9556	0.002
Hs.138211	MAPK8	−3.9479	<0.001
Hs.292156	DKK3	−3.9375	<0.001
Hs.40735	FZD3	−3.9292	0.049
Hs.516646	CREB1	−3.8994	<0.001
Hs.463978	MAP2K6	−3.4831	0.044
Hs.712929	CTNNB1	−3.2242	<0.001
Hs.23348	SKP2	−3.1765	0.03
Hs.194698	CCNB2	−3.1619	0.025
Hs.523852	CCND1	−3.1179	0.03
Hs.643085	WNT5A	−2.8536	0.027
Hs.445884	WNT3	−2.5029	0.002
Hs.654934	DAAM1	−2.4984	0.002
Hs.258575	WNT2B	−2.4898	0.002
Hs.512714	WNT7B	−2.4728	0.002
Hs.485233	MAPK14	−2.4269	0.037
Hs.644231	ETS2	−2.1205	<0.001
Hs.437460	p53	−2.08	<0.001
Hs.19192	CDK2	−2.0198	<0.001
Hs.408528	RB1	−2.0135	<0.001
Hs.234521	MAPKAPK3	−1.9963	<0.001
Hs.696684	JUN	−1.9679	<0.001
Hs.248164	WNT1	−1.9091	<0.001
Hs.592510	ATF2	−1.8732	<0.001
Hs.57732	MAPK11	−1.8633	<0.001
Hs.306051	WNT5B	−1.7533	0.005
Hs.145605	MAP3K2	1.8447	0.004
Hs.390428	MAP3K4	1.8914	<0.001
Hs.514012	MAP2K3	1.9496	<0.001
Hs.643566	MAPKAPK2	1.9993	<0.001
Hs.40499	DKK1	2.0323	<0.001
Hs.433332	LAMTOR3	2.0336	<0.001
Hs.202453	MYC	2.0639	<0.001
Hs.649965	MEF2C	2.1279	0.001
Hs.326035	EGR1	3.1509	0.025
Hs.627078	CXADR	3.2143	0.002